In a small saucepan, melt the butter over medium heat and continue to cook, swirling occasionally, until butter turns golden brown and has a nutty aroma. Remove from heat and pour into a small bowl.
In a large microwavable safe bowl, combine the Chex cereal, pretzels, and Cheerios. Stir to combine.
Add the Worcestershire sauce, seasoned salt, garlic powder, and onion powder to the brown butter. Stir until combined. Pour butter mixture over the cereal mixture and stir until evenly coated.
Microwave uncovered on high for 5 to 6 minutes, thoroughly stirring every 2 minutes. Spread Chex Mix on paper towels to cool. Store in airtight container.
Note-you can make this in the oven. Preheat the oven to 250 degrees F. After you pour the butter mixture over the cereal mixture and stir, pour the Chex Mix on a large baking sheet and place in the oven for one hour. Stir every 10-15 minutes. Remove from the oven and cool before eating!